In 2025, I am excited to talk to more friends and clients about hormone replacement therapy. We offer some services already at the A-List Clinic and it’s my goal to expand our expertise in the coming year. It’s not just a resolution, it’s a promise!
That said, I wanted to paint a broad overview this week of how hormone replacement therapy (HRT) and GLP-1s have overlap and differences. Mostly important, both methods are grounded in understanding and working with the body’s biology, but they address different underlying issues. To make informed decisions, it’s important to understand their mechanisms, similarities, differences, and how each may contribute to weight loss.
What Are GLP-1 Medications?
I’ve waxed poetic GLP-1 medications, such as semaglutide (i.e. Ozempic and Wegovy), several times. In shortest terms, these medications belong to a class of drugs that mimic the action of the glucagon-like peptide-1 hormone. This hormone plays a critical role in:
- Regulating blood sugar levels.
- Slowing stomach emptying to help you feel full longer.
- Suppressing appetite by signaling the brain to reduce hunger.
These medications were originally developed for managing type 2 diabetes but have since shown remarkable efficacy for weight loss in both diabetic and non-diabetic individuals.
Key benefits of GLP-1 medications for weight loss:
- Appetite Control: Helps individuals consume fewer calories without feeling deprived.
- Weight Loss Results: Clinical trials have demonstrated significant weight loss when combined with a healthy diet and exercise.
- Improved Metabolism: Helps regulate insulin and glucose levels, which are often out of balance in people with obesity.
What Is Hormone Replacement Therapy (HRT)?
HRT involves supplementing or replacing hormones like estrogen, progesterone, or testosterone, which naturally decline with age, menopause, or certain medical conditions. These hormones influence many bodily functions, including metabolism, muscle mass, and fat distribution.
Key benefits of HRT for weight management:
- Addressing Hormonal Imbalances: Correcting deficiencies in estrogen or testosterone can help restore a healthier metabolism.
- Fat Distribution: HRT can reduce abdominal fat and improve overall body composition.
- Energy Levels and Mood: Improved energy and emotional well-being make it easier to engage in physical activity and maintain a healthy lifestyle.
Basically, HRT can play an important role in addressing weight changes caused by hormonal imbalances– but it’s not limited to issues of weight loss or weight gain.
Similarities Between GLP-1 Medications and HRT
- Biological Focus: Both GLP-1 medications and HRT target biological processes that influence weight. GLP-1 medications regulate hunger and glucose metabolism, while HRT addresses hormonal imbalances affecting metabolism and fat storage.
- Improved Health Beyond Weight Loss: Both treatments offer broader health benefits. GLP-1 medications help manage type 2 diabetes and reduce cardiovascular risk, while HRT improves bone density, mood, and symptoms of menopause.
- Tailored to the Individual: Both approaches require a personalized plan based on medical history, current health status, and weight loss goals.
Differences Between GLP-1 Medications and HRT
| Feature | GLP-1 Medications | Hormone Replacement Therapy (HRT) |
|---|---|---|
| Primary Purpose | Weight loss and type 2 diabetes management | Hormonal balance, menopause, or aging-related health concerns |
| Mechanism of Action | Mimics GLP-1 hormone to suppress appetite and regulate blood sugar | Replenishes declining hormones like estrogen, progesterone, or testosterone |
| Efficacy for Weight Loss | Specifically designed to support significant weight loss | Supports weight loss indirectly by addressing hormonal issues |
| Target Population | Individuals with obesity or type 2 diabetes | Individuals with hormonal deficiencies or imbalances |
| Administration | Weekly injections or daily pills | Patches, pills, gels, or injections |
How Each Contributes to Weight Loss
GLP-1 Medications:
- Directly reduce calorie intake by curbing appetite and increasing satiety.
- Have demonstrated an average weight loss of 10-15% of body weight in clinical trials.
HRT:
- Improves metabolic function by restoring hormone levels.
- Reduces fat accumulation associated with menopause or low testosterone.
Are These Treatments Complementary?
In some cases, combining GLP-1 medications with HRT may provide synergistic benefits. For example, an individual experiencing weight gain due to menopause may benefit from HRT to address hormonal imbalances, while GLP-1 medication can provide additional appetite control and metabolic support.
However, these treatments should only be combined under the guidance of a healthcare professional to ensure safety and effectiveness.
Potential Risks and Considerations
- GLP-1 Medications: May cause nausea, vomiting, or gastrointestinal discomfort in some individuals. These medications are not recommended for people with a history of certain thyroid conditions.
- HRT: Carries potential risks, such as blood clots, stroke, or certain cancers, depending on the type and duration of therapy. These risks must be weighed against the benefits.
Consultation with a healthcare provider is essential to evaluate which treatment—or combination—is right for you.
Next Steps: What’s Right for You?
Understanding the similarities and differences between GLP-1 medications and hormone replacement therapy highlights the importance of a tailored approach to weight loss. Your unique biology, health history, and goals should guide the decision-making process.
If you’re ready to explore your options, schedule a consultation with The A-List Clinic. We specialize in evidence-based solutions to help you achieve your weight loss and health goals.
